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Name: Allergy and Allergic Diseases (2-th edition), Volume 1 + Volume 2
Author: Barry Kay, Allen Kaplan, Jean Bousquet, Patrick Holt
Book type: Manual
Published: 2009 y.
Size: 32.6 mb
Format: PDF
Publishing house: Wiley-Blackwell, UK.
Number of pages: 2184

The scope and breadth of allergy and allergic diseases has increased enormously since the first edition of this textbook was published in 1997. Our present aim, as before, is to provide a detailed, up-to-date and authoritative source of information on both the scientific basis and clinical aspects of our subject. Barry Kay is delighted to be joined by Allen Kaplan, Jean Bousquet and Patrick Holt as co-editors of this two-volume work. We have attempted to cover all important aspects of the field. This includes growing areas on the immunological basis of allergy, particularly regulatory T cells, environmental factors in IgE production and innate immunity, as well as up to date accounts of the cells and mediators of allergic inflammation. Furthermore, the sections on pharmacology, physiology, allergens and animals models have all been fully revised. In Volume 2, the clinical section, we have dealt in detail with allergic conjunctivo-rhinitis, asthma, eosinophilic disorders, allergy and the skin, anaphylaxis, food and drug allergy and allergy prevention. We have also addressed current approaches to treatment with emphasis on internationally agreed guidelines and there is a substantial section on allergen immunotherapy, including recent advances.

A. Barry Kay
Allen P. Kaplan
Jean Bousquet
Patrick G. Holt

The second edition of Allergy and Allergic Diseases is a timely, all-encompassing two-volume text that covers in detail the basic science at the heart of the specialty and its major and minor clinical components. The pathobiology links back to the basic sciences through both clinical findings and translational research. There is insightful emphasis not only on pathogenesis, but also on underlying genetic and environmental factors uncovered through genomics and epidemiology, respectively.
The figures, photographs, tables and diagrams reflect their editorial wisdom in their clarity and value to the text. Similarly, the sharing of editorial responsibilities has not only resulted in a thoughtful selection of the subject matter but also in a superb selection of authors to assure that each presentation has depth and balance. These authors are international in distribution and widely acknowledged for their comprehension of their subject.
Subjects are often covered in several chapters so as to provide history, preclinical knowledge, and clinical meaning in terms of pathobiology and intervention. For example, IgE is addressed from history, to crystal structure, to effects of indoor and outdoor pollution, to neutralization by monoclonal antibodies; leukotrienes are considered from history, to chemical and biological properties, to small molecule inhibitors; eosinophils are covered from discovery, to function, to monoclonal antibody neutralization of the chemokines/cytokines that regulate function; and the pathobiology of many conditions is presented from in situ findings of cell types, pathways, and soluble effectors through analysis of animal models and the human condition.

K. Frank Austen MD
Harvard Medical School

List of Contributors, ix
Foreword, xvii
Preface, xviii

The Scientific Basis of Allergy

Part 1 Immunology of the Allergic Response

1 Allergy and Hypersensitivity: History and Concepts
2 Development of Allergy and Atopy
3 T Cells and Cytokines in Asthma and Allergic Inflammation
4 Regulatory T Cells and Other Tolerogenic Mechanisms in Allergy and Asthma
5 IgE and IgE Receptors
6 Immunoglobulin Gene Organization and Expression and Regulation of IgE
7 Environmental Factors in IgE Production
8 Antigen-presenting Dendritic Cells and Macrophages
9 Innate Immunity in Allergic Disease
10 Signal Transduction in Allergic and Inflammatory

Part 2 Inflammatory Cells and Mediators

11 Mast Cells: Biological Properties and Role in Health and Allergic Diseases
12 Eosinophils: Biological Properties and Role in Health and Disease
13 Neutrophils: Biological Properties and Role in Health and Allergic Diseases
14 Basophils: Biological Properties and Role in Allergic Diseases
15 Leukocyte Adhesion in Allergic Inflammation
16 Airway Epithelium
17 Airway Vascularity in Asthma
18 Fibroblasts and the Extracellular Matrix
19 Immune Complexes and Complement: Their Role in Host Defense and in Disease
20 Bradykinin Pathways and Allergic Disease
21 Chemokines
22 Neurotrophins
23 Neuropeptides
24 Late-phase Allergic Reactions in Humans

Part 3 Pharmacology

25 Antihistamines,
26 Lipid Mediators: Leukotrienes, Prostanoids, Lipoxins, and Platelet-activating Factor
27 Theophylline and Isoenzyme-selective Phosphodiesterase Inhibitors
28 Adrenergic Agonists and Antagonists
29 Cholinergic Antagonists
30 Antileukotriene Agents
31 Glucocorticosteroids
32 Immunomodulating Drugs

Part 4. Physiology

33 Physiologic Aspects of Asthma
34 Aerosol Delivery Systems
35 Bronchial Hyperresponsiveness
36 Exercise-induced Bronchoconstriction: Animal Models
37 Exercise-induced Bronchoconstriction: Human Models
38 Sensory and Autonomic Nervous System in Asthma and Rhinitis
39 Mucus and Mucociliary Clearance in Asthma and Allergic Rhinitis
40 Biology of Vascular Permeability
41 Airway Smooth Muscle

Part 5. Allergens

42 Biochemistry of Allergens and Recombinant Allergens
43 Host Responses to Allergens
44 Allergen Extracts and Standardization
45 Grass, Tree, and Weed Pollen
46 Fungi as Allergens
47 Dust Mites and Asthma
48 Animal Allergens
49 Airborne Allergens and Irritants in the Workplace
50 Allergens from Stinging Insects: Ants, Bees, and Vespids
51 Cockroach Allergens, Environmental Exposure, and Asthma
52 Food Allergens
53 Latex Allergy

Part 6. Animal Models of Asthma

54 Primate Models of Allergic Asthma
55 Airway Remodeling in Small Animal Models
56 Are Animal Models of Asthma Useful?


Allergic Diseases: Etiology, Diagnosis and Treatment

Part 7. Etiology and Pathology

57 Genetics of Asthma and Atopic Dermatitis
58 Epidemiology of Asthma, Atopy, and Atopic Disease
59 The Allergy March
60 Outdoor Air Pollution and Allergic Airway Disease
61 Indoor Air Pollution
62 Molecular Immunopathology of Allergic Disease

Part 8. Diagnosis of Allergic Disease

63 Principles and Practice of Diagnosis and Treatment of Allergic Disease
64 Skin Testing in Diagnosis and Management of Respiratory Allergic Diseases,
65 Allergy Testing in the Laboratory
66 Measurement of Markers of Inflammation in Induced Sputum and Exhaled Air

Part 9. Allergic Rhinoconjunctivitis and Immunotherapy

67 Definition and Classification of Allergic Rhinitis and Upper Airways Diseases
68 Pathophysiology of Allergic Rhinitis
69 Management and Treatment of Allergic Rhinitis
70 Nasal Polyps and Rhinosinusitis
71 Ocular Allergy
72 Mechanisms in Allergen Injection Immunotherapy
73 Allergen Injection Immunotherapy: Indications and Practice
74 Sublingual Immunotherapy
75 Novel Approaches to Allergen Immunotherapy

Part 10. Asthma and its Treatment

76 Definition, Clinical Features, Investigations, and Differential Diagnosis of Asthma
77 Asthma in Infancy and Childhood
78 Pathogenesis of Asthma
79 Pathology of Asthma
80 Management of Chronic Asthma
81 Anti-IgE in Persistent Severe Allergic Asthma
82 Occupational Asthma
83 New Drugs for the Treatment of Allergy and Asthma

Part 11. Eosinophil-associated Disease and Hypersensitivity Pneumonitis

84 Allergic Bronchopulmonary Aspergillosis
85 Extrinsic Allergic Alveolitis/Hypersensitivity Pneumonitis
86 Pulmonary Eosinophilia
87 Hypereosinophilic Syndromes

Part 12. Allergy and the Skin

88 Atopic Dermatitis
89 Contact Dermatitis
90 Urticaria and Angioedema
91 Mastocytosis

Part 13. Anaphylaxis and Allergy to Food and Drugs

92 Anaphylaxis
93 Food Allergy and Eosinophilic Gastroenteropathies
94 Drug Hypersensitivity
95 Hypersensitivity to Aspirin and other NSAIDs
96 Insect Sting Allergy

Part 14. Prevention of Allergic Disease

97 Prevention of Allergic Disease
98 Prevalence of Atopic Disorders in a Developing World: Pitfalls and Opportunities


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