Pictures on allergology
 
Properties and structure of IgE and IgE receptors
 
 
views views: 1298     downloads downloads: 1     votes: 1     rating: rating     added: 2017-07-20     updated: 2017-07-20
 
Properties and structure of IgE and IgE receptors

Cytotoxic T lymphocytes. APT - antigen-presenting cell

Name: Properties and structure of IgE and IgE receptors
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Keywords: Allergy, allergy pictures, pictures on allergology, allergology photo, pictures on allergic diseases, pictures on allergies, properties and structure of IgE and IgE receptors, properties of IgE and IgE receptors, structure of IgE and IgE receptors, properties of IgE, properties of IgE receptors, structure of IgE, structure of IgE receptors, receptors for the Fc fragment of the immunoglobulin, receptors for the Fc fragment, domain structure of the heavy chain IgE, heavy chain IgE, the binding sites for the high affinity lgE receptor of the mast cell - FcεRI and the low affinity lgE receptor - FcεRII are shown, the binding sites for the high affinity lgE receptor, high affinity lgE receptor, lgE receptor of the mast cell, FcεRI lgE receptor, low affinity lgE receptor, structure and characteristics of surface receptors for the Fc fragment, structure of surface receptors for the Fc fragment, structure of surface receptors, characteristics of surface receptors for the Fc fragment, characteristics of surface receptors, affinity, binding of monomer, binding of aggregated, expression, monocyte, macrophage, neutrophil, NK cell, B-cell, mast cell, glycosylated phosphatidylinositol anchors, phosphatidylinositol anchors, FCεRI, FCεRII, FCγRI, FCγRII, FCγRIII-B, FCγRIII-A, cytoplasmic peptide tail, FceRI, FceRII mast cell receptor, Ce1, Ce2, Ce3, Ce4, cytoplasmic peptide tail, Variable, constant regions of IgE, 2e-Ar-determinants.

Note:

The heavy chain IgE domain structure, binding sites for the high affinity IgE receptor of the mast cell - FcεRI and the low affinity IgE receptor FcεRII. Structure and characteristics of surface receptors for the Fc fragment.

IgE is a glycoprotein with Mr 190000 and a sedimentation coefficient of 8S. IgE is a glycoprotein with Mr 190000 and a sedimentation coefficient of 8S. Similarly to other Ig, the IgE molecule consists of 4 chains - 2 lungs and 2 heavy ones. Heavy chains of the ε-type, which determine the class specificity of this protein, contain 5 domains (1 in the variable and 4 in the constant regions). When splitting with papain, an Fc fragment containing 2 ε-Ar determinants and 2 Fab fragments are formed, into which the Arg binding sites are formed. The tertiary structure of the Fc fragment provides the ability of the molecule to fix on the FceRI receptor membranes tCl and basophils. Presented on TCL, basophils and Langerhans cells of human skin, FceRI refers to the high affinity receptors for IgE. With the help of molecular biology methods, genes encoding the human IgE ε chain are cloned. The binding site of IgE with the FceRI receptor is localized in Cε2- and partially in the Cε3 domains of the heavy chain. The high affinity FceRI receptor for IgE consists of α-, β- and two γ-chains, of which only the α chain binds IgE. Β- and γ-chains are involved in signal transmission when IgE is bound to an allergen, resulting in the release of mediators.


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